Hypercalcaemia is a common finding in both dogs and cats. In the dog common presentation is PUPD and hypercalcaemia is a differential that must be excluded when PUPD is the presenting clinical sign. In the cat clinical signs are often vague with anorexia as the most common clinical sign. The webinar will focus on pathogenesis and discuss parathyroid dependent as well as parathyroid independent hypercalcaemia. The difference between total calcium and ionised calcium will be discussed and its use in diagnosis along with the parathyroid hormone as well as the use of parathyroid related hormone, vitamin D and calcitriol. Sample management and submission will also be covered. Treatment will be mentioned at the end but will not be extensively discussed.